Osteoblast-Derived Factors Induce Androgen-Independent Proliferation and Expression of Prostate-Specific Antigen in Human Prostate Cancer Cells Academic Article uri icon

Overview

MeSH Major

  • Cord Blood Stem Cell Transplantation
  • Fetal Blood
  • Hematologic Neoplasms
  • Transplantation Conditioning

abstract

  • Osteoblasts secrete factors, such as IL-6, that cause androgen-independent induction of PSA gene expression and proliferation of prostate cancer cells by a mechanism that partially relies on the AR. Identifying such molecular mechanisms may lead to improved clinical management of metastatic prostate cancer.

publication date

  • March 2004

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-0974-3

Additional Document Info

start page

  • 1860

end page

  • 9

volume

  • 10

number

  • 5