G Protein-Coupled Receptor-Dependent Development of Human Frontal Cortex Academic Article uri icon

Overview

MeSH Major

  • Cerebral Cortex
  • Frontal Lobe
  • Receptors, G-Protein-Coupled

abstract

  • The mammalian cerebral cortex is characterized by complex patterns of anatomical and functional areas that differ markedly between species, but the molecular basis for this functional subdivision is largely unknown. Here, we show that mutations in GPR56, which encodes an orphan G protein-coupled receptor (GPCR) with a large extracellular domain, cause a human brain cortical malformation called bilateral frontoparietal polymicrogyria (BFPP). BFPP is characterized by disorganized cortical lamination that is most severe in frontal cortex. Our data suggest that GPCR signaling plays an essential role in regional development of human cerebral cortex.

publication date

  • March 26, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1126/science.1092780

PubMed ID

  • 15044805

Additional Document Info

start page

  • 2033

end page

  • 6

volume

  • 303

number

  • 5666