Simvastatin decreases myocardial tumor necrosis factor α content in heart transplant recipients Academic Article uri icon

Overview

MeSH Major

  • Heart Transplantation
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Myocardium
  • Simvastatin
  • Tumor Necrosis Factor-alpha

abstract

  • Simvastatin treatment in heart transplant recipients decreased myocardium TNF-alpha expression. This decrease did not translate into a difference in the markers of hypertrophy. However, decreased myocardial TNF-alpha may be a marker of a general statin-mediated decrease in inflammation in the transplanted heart that leads to improved graft and patient survival.

publication date

  • January 2005

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.healun.2003.09.037

PubMed ID

  • 15653378

Additional Document Info

start page

  • 46

end page

  • 51

volume

  • 24

number

  • 1