Toll-like receptor-4 and allograft responses Academic Article uri icon

Overview

MeSH Major

  • Graft Rejection
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Skin Transplantation

abstract

  • Signaling through toll-like receptors (TLRs) is believed to be the critical first step in the activation of antigen presenting cells and the initiation of adaptive immune responses. Of these receptors, TLR-4 particularly recognizes endogenous agonists and may be important for allograft responses. We tested this concept using mice with defective function and structure of TLR-4 as recipients of grafts across major and minor histocompatibility barriers. The kinetics of rejection was the same in mutant mice and wild-type controls. Our results highlight an important difference between alloimmune and conventional immune responses.

publication date

  • February 15, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/01.TP.0000110792.38434.F4

PubMed ID

  • 14966433

Additional Document Info

start page

  • 475

end page

  • 7

volume

  • 77

number

  • 3