Diabetic Mouse Angiopathy Is Linked to Progressive Sympathetic Receptor Deletion Coupled to an Enhanced Caveolin-1 Expression Academic Article uri icon

Overview

MeSH Major

  • Caveolins
  • Diabetes Mellitus, Type 1
  • Diabetic Angiopathies
  • Receptors, Adrenergic, alpha-1
  • Receptors, Adrenergic, beta-2

abstract

  • Our results show that in diabetes development, there is a progressive selective downregulation of the alpha1 and beta2 receptors. At the same time, there is an increased expression of caveolin-1, the endogenous eNOS inhibitory protein. Thus, caveolin-1 could represent a new possible therapeutic target in vascular impairment associated with diabetes.

publication date

  • April 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/01.ATV.0000122362.44628.09

PubMed ID

  • 14962949

Additional Document Info

start page

  • 721

end page

  • 6

volume

  • 24

number

  • 4