IL-7 and IL-15: Therapeutic cytokines for immunodeficiency Review uri icon

Overview

MeSH Major

  • Acquired Immunodeficiency Syndrome
  • Immunotherapy
  • Interleukin-15
  • Interleukin-7

abstract

  • Immunodeficiency due to inborn errors, infections, autoimmune diseases and the toxicity of certain therapies, has become an important clinical challenge. Strategies to enhance immune function could improve the outcome for a considerable number of patients. Although myeloid growth factors have found widespread use in clinical medicine, a 'lymphoid growth factor' has not yet been established in clinical use. Several recent studies have proposed two candidate immunostimulatory cytokines: interleukin-7 (IL-7) and IL-15. In this Review, we discuss recent findings regarding the effects of IL-7 and IL-15 on lymphopoiesis and their potential use for the treatment of immunodeficiency.

publication date

  • January 2005

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.it.2004.11.002

PubMed ID

  • 15629410

Additional Document Info

start page

  • 56

end page

  • 64

volume

  • 26

number

  • 1