Toward Optimal Tissue Sealants for Neurosurgery: Use of a Novel Hydrogel Sealant in a Canine Durotomy Repair Model Academic Article uri icon

Overview

MeSH Major

  • Dura Mater
  • Methylgalactosides
  • Tissue Adhesives

abstract

  • The hydrogel-treated animals exhibited normal progression of dural healing, no dural adhesions, and no underlying effects on the brain. Although dural healing progressed normally, the control animals displayed marked peridural adhesions. The results of this in vivo study suggest that hydrogels, such as that used here, may significantly decrease cerebrospinal fluid leakage, thereby increasing the safety and effectiveness of dural closure in patients and facilitating surgical reexploration.

publication date

  • November 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 14580287

Additional Document Info

start page

  • 1189

end page

  • 98; discussion 1198-9

volume

  • 53

number

  • 5