Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior: KIT mutation analysis and clinical correlates of 120 gastrointestinal stromal tumors Academic Article uri icon

Overview

MeSH Major

  • Gastrointestinal Neoplasms
  • Mutation
  • Proto-Oncogene Proteins c-kit

abstract

  • Most KIT-expressing GISTs show KIT mutations that are preferentially located within the classic hot spot of exon 11. In addition, we found an association between a second hot spot at the 3'end of exon 11, characterized by ITDs, and a subgroup of clinically indolent gastric GISTs in older females. KIT exon 9 mutations seem to define a distinct subset of GISTs, located predominantly in the small bowel and associated with an unfavorable clinical course.

publication date

  • September 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 12960119

Additional Document Info

start page

  • 3329

end page

  • 37

volume

  • 9

number

  • 9