The role of autosomal cell apoptosis regulator genes in human spermatogenesis. Academic Article uri icon

Overview

abstract

  • Immunohistochemical analysis of the expression of the autosomal apoptosis regulator genes, BAX, bcl-2, p53, and cyclic-AMP responsive element modulator (CREM) in testis biopsies from infertile men demonstrated that BAX, bcl-2, and p53 immunoreactivity was absent irrespective of seminiferous tubule histology. In contrast, cell-specific CREM immunoreactivity in round spermatids, with complete absence of CREM in patient biopsies showing spermatocyte maturation arrest and Sertoli cell only, was evident, suggesting a possible role of autosomal genes in the regulation of apoptosis in human spermatogenesis regulation.

publication date

  • January 1, 1999

Research

keywords

  • Apoptosis
  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • Proto-Oncogene Proteins c-bcl-2
  • Repressor Proteins
  • Spermatogenesis
  • Tumor Suppressor Protein p53

Identity

Scopus Document Identifier

  • 0032823381

PubMed ID

  • 10481969

Additional Document Info

volume

  • 31

issue

  • 2