The role of mitomycin C in preventing synechia and stenosis after endoscopic sinus surgery. Academic Article uri icon

Overview

MeSH

  • Administration, Topical
  • Adult
  • Aged
  • Constriction, Pathologic
  • Endoscopy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Single-Blind Method

MeSH Major

  • Mitomycin
  • Nucleic Acid Synthesis Inhibitors
  • Otorhinolaryngologic Surgical Procedures

abstract

  • Synechia and stenosis formation after endoscopic sinus surgery (ESS) represents a potential source of surgical failure. Mitomycin C (MMC) has been used successfully in other fields to decrease postoperative scar formation. We hypothesize that the topical application of MMC reduces the incidence of stenosis and synechia formation after ESS. This study is a randomized, controlled, single-blinded study based in a tertiary care teaching hospital. After routine ESS, a pledget soaked in MMC (0.5%) was randomly placed into the middle meatus of one nasal cavity for 5 minutes and a pledget soaked in saline was placed in the contralateral side in each patient. A blinded observer followed the patients for any evidence of stenosis or synechia formation. The medical records of enrolled patients were reviewed for demographics, diagnosis, prior surgery, type of sinus surgery, complications, incidence of stenosis/synechia, and need for further procedures. Twenty-nine patients were included in the final analysis. The mean follow-up period was 15 months (range, 3-32 months). There were no complications in this series. Eight patients experienced 10 episodes of synechia formation and one patient experienced 1 episode of synechia formation and 1 episode of stenosis of the maxillary sinus ostium. Seven of the 12 episodes of synechia/stenosis occurred on the side of the MMC application and the remaining 5 episodes occurred on the side opposite to the MMC application. This difference was not statistically significant. The topical application of MMC did not decrease the incidence of stenosis and synechia formation after ESS.

publication date

  • October 2004
  • September 2004

has subject area

  • Administration, Topical
  • Adult
  • Aged
  • Constriction, Pathologic
  • Endoscopy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mitomycin
  • Nucleic Acid Synthesis Inhibitors
  • Otorhinolaryngologic Surgical Procedures
  • Prospective Studies
  • Single-Blind Method

Research

keywords

  • Clinical Trial
  • Journal Article
  • Randomized Controlled Trial

Identity

Language

  • eng

PubMed ID

  • 15586803

Additional Document Info

start page

  • 311

end page

  • 314

volume

  • 18

number

  • 5