Functional interplay between the macrophage scavenger receptor class B type I and pitavastatin (NK-104)
Anti-Inflammatory Agents, Non-Steroidal
Gene Expression Regulation
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Our data demonstrate that pitavastatin can stimulate macrophage SR-BI expression by reduction of cholesterol biosynthetic intermediates and antiinflammatory action and suggest additional pleiotropic effects of statins by which they may reduce the incidence of coronary heart disease.