Effectiveness of Prostaglandin El in Relieving Obstruction in Coarctation of the Aorta Without Opening the Ductus Arteriosus Academic Article Article uri icon


MeSH Major

  • Diagnostic Errors
  • Tetralogy of Fallot
  • Tracheal Stenosis


  • The two main theories regarding the pathogenesis of coarctation of the aorta are the Skodaic hypothesis of ductal tissue constricting the aorta at the level of the insertion of the ductus arteriosus and the flow theory of decreased ascending aortic blood flow in the fetus, which results in associated isthmic narrowing and a localized shelf. To document that ectopic ductal tissue constriction can cause coarctation of the aorta in the absence of a patent ductus arteriosus, we report three cases of infants presenting with critical coarctation who responded to prostaglandin E1 infusion without opening the ductus arteriosus.

publication date

  • January 2004



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1007/s00246-003-0549-5

PubMed ID

  • 15043008

Additional Document Info

start page

  • 49

end page

  • 52


  • 25


  • 1