Phase II Trial of Vinorelbine Plus Doxorubicin in Relapsed Small-Cell Lung Cancer: CALGB 9332 Academic Article Article uri icon


MeSH Major

  • Breast Neoplasms
  • Decision Making
  • Magnetic Resonance Imaging
  • Mammography
  • Mastectomy, Segmental
  • Neoadjuvant Therapy


  • Small-cell lung cancer that progresses after initial response may still be sensitive to systemic treatment. This study assessed doxorubicin plus vinorelbine tartrate (Navelbine Injection) in patients who had no prior exposure to these agents. Treatment consisted of vinorelbine at 25 mg/m2 on days 1 and 8 and doxorubicin at 50 mg/m2 on day 1 of each 21-day cycle. The trial was stopped early because of excessive toxicity. The partial response rate was 26.7%. Toxicities included grade IV neutropenia in 73%, and febrile neutropenia and/or sepsis in 60%. Three patients died from sepsis during cycle 1. Performance status 2 was significantly associated with febrile neutropenia (p = 0.044). Although this regimen had some activity, the toxicity precluded further evaluation.

publication date

  • February 2004



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1097/01.coc.0000045850.98788.ED

PubMed ID

  • 14758128

Additional Document Info

start page

  • 19

end page

  • 23


  • 27


  • 1