Cytomegalovirus Infection Impairs the Nitric Oxide Synthase Pathway: Role of Asymmetric Dimethylarginine in Transplant Arteriosclerosis Academic Article uri icon

Overview

MeSH Major

  • Arginine
  • Coronary Artery Disease
  • Cytomegalovirus Infections
  • Heart Transplantation
  • Nitric Oxide Synthase

abstract

  • CMV infection in human heart transplant recipients is associated with higher ADMA elevation and more severe TA. CMV infection in endothelial cells increases oxidative stress, impairs DDAH activity, and increases ADMA elaboration. CMV infection may contribute to endothelial dysfunction and TA by dysregulation of the endothelial nitric oxide synthase pathway.

publication date

  • February 3, 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/01.CIR.0000109692.16004.AF

PubMed ID

  • 14732750

Additional Document Info

start page

  • 500

end page

  • 5

volume

  • 109

number

  • 4