Enhanced cellular immune response in women with PTSD related to childhood abuse. Academic Article uri icon

Overview

MeSH

  • Adult
  • Child
  • Child Abuse, Sexual
  • Circadian Rhythm
  • Comorbidity
  • Female
  • Humans
  • Hydrocortisone
  • Immunity, Cellular
  • Saliva
  • Skin Tests

MeSH Major

  • Child Abuse
  • Hypersensitivity, Delayed
  • Stress Disorders, Post-Traumatic

abstract

  • Disturbed regulation of both the hypothalamic-pituitary-adrenal (HPA) axis and the sympathoadrenomedullary system in posttraumatic stress disorder (PTSD) suggests that immune function, which is modulated by these systems, also may be dysregulated in individuals with PTSD. Delayed-type hypersensitivity skin test responses were measured in 16 women with PTSD due to childhood sexual or physical abuse and 15 women who did not have a history of abuse, other trauma, or psychiatric disorders. HPA axis activity was assessed by examination of circadian salivary cortisol levels and a single time point measurement of plasma cortisol. Delayed-type hypersensitivity was enhanced in women with PTSD. Cortisol measures did not differ between PTSD and healthy comparison subjects. These results suggest that cell-mediated inflammatory reactions are greater in individuals with PTSD.

publication date

  • September 2003

has subject area

  • Adult
  • Child
  • Child Abuse
  • Child Abuse, Sexual
  • Circadian Rhythm
  • Comorbidity
  • Female
  • Humans
  • Hydrocortisone
  • Hypersensitivity, Delayed
  • Immunity, Cellular
  • Saliva
  • Skin Tests
  • Stress Disorders, Post-Traumatic

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1176/appi.ajp.160.9.1705

PubMed ID

  • 12944352

Additional Document Info

start page

  • 1705

end page

  • 1707

volume

  • 160

number

  • 9