Assessment of treatment response by autoradiography with 14C-aminocyclopentane carboxylic acid, 67Ga-DTPA, and 18F-FDG in a herpes simplex virus thymidine kinase/ganciclovir brain tumor model Academic Article uri icon

Overview

MeSH Major

  • Autoradiography
  • Brain Neoplasms
  • Cycloleucine
  • Fluorodeoxyglucose F18
  • Gallium Radioisotopes
  • Ganciclovir
  • Genetic Therapy
  • Pentetic Acid
  • Simplexvirus
  • Thymidine Kinase

abstract

  • (14)C-ACPC influx, K(1)(ACPC), facilitated transport, partial differential K(1)(ACPC), and % dose/g (ACPC) are good indicators of early treatment response after HSV-tk/GCV gene therapy. The parametric images and changes in K(1)(ACPC), partial differential K(1)(ACPC), and % dose/g (ACPC) are substantial and are better than the corresponding measures obtained in the same animals and in the same tissue (tumor) regions with (67)Ga-DTPA and (18)F-FDG. Amino acid transport imaging may be a good surrogate paradigm to monitor treatment response of brain tumors.

publication date

  • November 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 14602869

Additional Document Info

start page

  • 1845

end page

  • 54

volume

  • 44

number

  • 11