Greater availability of brain dopamine transporters in major depression shown by [99mTc]TRODAT-1 SPECT imaging
Depressive Disorder, Major
Membrane Transport Proteins
Tomography, Emission-Computed, Single-Photon
Dopamine transporter affinity may be higher than normal in the basal ganglia of depressed patients. These findings suggest that dopamine function may be altered in depression and may also be a mechanism of antidepressant activity.