Rheb fills a GAP between TSC and TOR Review uri icon

Overview

MeSH Major

  • Monomeric GTP-Binding Proteins
  • Neuropeptides
  • Protein Kinases
  • Proteins
  • Repressor Proteins
  • Signal Transduction

abstract

  • There has been much interest in determining the molecular and cellular functions of hamartin and tuberin, which are encoded by the genes TSC1 and TSC2 that are mutated in the tuberous sclerosis complex disease. Recently, several laboratories have independently reported a major breakthrough in this field. Together, these genetic, biochemical and cell-biological studies have demonstrated that the tuberin-hamartin complex inhibits target of rapamycin (TOR) signaling by acting as a GTPase-activating protein for the Ras-related small G protein Rheb.

publication date

  • November 2003

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.tibs.2003.09.003

PubMed ID

  • 14607085

Additional Document Info

start page

  • 573

end page

  • 6

volume

  • 28

number

  • 11