Altered glucose metabolism in microvessels from patients with Alzheimer's disease Academic Article uri icon

Overview

MeSH Major

  • Alzheimer Disease
  • Blood Vessels
  • Deoxy Sugars
  • Deoxyglucose
  • Energy Metabolism
  • Hexokinase
  • Temporal Lobe

abstract

  • Microvessels isolated from temporal cortex of patients with Alzheimer's disease showed decreased uptake of glucose when compared with vessels from age-matched or young control subjects. This was due to decreased hexokinase activity in the Alzheimer samples, as determined by ion exchange chromatography. This finding was confirmed independently by determination of the phosphorylation constant for hexokinase, K3, using positron emission tomography. The results suggest that Alzheimer's disease may result from a global defect in brain energy metabolism.

publication date

  • January 1989

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/ana.410260114

PubMed ID

  • 2774504

Additional Document Info

start page

  • 91

end page

  • 4

volume

  • 26

number

  • 1