Dimethylarginine Dimethylaminohydrolase Regulates Nitric Oxide Synthesis: Genetic and Physiological Evidence Academic Article uri icon

Overview

MeSH Major

  • Amidohydrolases
  • Arginine
  • Nitric Oxide

abstract

  • DDAH I overexpression increases NOS activity in vitro and in vivo. The hDDAH-1 transgenic animal exhibits a reduced systolic blood pressure, systemic vascular resistance, and cardiac stroke volume. This study provides compelling evidence that the elaboration and metabolism of endogenous ADMA plays an important role in regulation of NOS activity.

publication date

  • December 16, 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/01.CIR.0000101924.04515.2E

PubMed ID

  • 14638548

Additional Document Info

start page

  • 3042

end page

  • 7

volume

  • 108

number

  • 24