Polymorphism in intron 2 of the fetal interleukin-1 receptor antagonist genotype influences midtrimester amniotic fluid concentrations of interleukin-1β and interleukin-1 receptor antagonist and pregnancy outcome Academic Article Article uri icon

Overview

MeSH Major

  • DNA
  • Genome-Wide Association Study
  • Nucleic Acid Amplification Techniques
  • Premature Birth
  • Specimen Handling

abstract

  • Possession by the fetus of the IL1RN*2 allele is associated with enhanced intraamniotic IL-1beta production. Induction of an intra-amniotic proinflammatory immune response might be more likely to lead to preterm labor in fetuses carrying the IL1RN*2 allele.

publication date

  • November 2003

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1067/S0002-9378(03)00630-6

PubMed ID

  • 14634579

Additional Document Info

start page

  • 1413

end page

  • 7

volume

  • 189

number

  • 5