The antitumor effects of interferon-alpha are maintained in mice challenged with a STAT1-deficient murine melanoma cell line Article Conference Paper uri icon

Overview

MeSH Major

  • Graft Rejection
  • Lung Transplantation
  • Terminology as Topic

abstract

  • This data suggests that IFN-alpha can enhance survival in an animal model where STAT1-mediated signal transduction and gene regulation is absent within the tumor but is present within the host. This data also indicates that the overexpression of STAT1 within the tumor does not significantly enhance the effects of exogenously administered IFN-alpha in this model. These findings indicate that the bulk of the antitumor actions of IFN-alpha may be derived from its effects on host tissues.

publication date

  • January 2004

Research

keywords

  • Conference Paper

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.jss.2003.09.005

PubMed ID

  • 14732359

Additional Document Info

start page

  • 129

end page

  • 36

volume

  • 116

number

  • 1