Methods to avoid adverse effect of circulating antigen on biodistribution of 125I-labeled antiTac dsFv: Preinjection of intact antibody versus clearance of antigen with avidin-biotin system Academic Article uri icon

Overview

MeSH Major

  • Antibodies, Monoclonal
  • Avidin
  • Immunoglobulin Fragments
  • Iodine Radioisotopes
  • Receptors, Interleukin-2

abstract

  • Preinjection of either HuTac or bt-HuTac with avidin chase improved the biodistribution of subsequently administered 125I-labeled antiTac dsFv by preventing the dsFv from binding to the sIL-2Ralpha, but the HuTac blocking method is simpler and longer lasting.

publication date

  • August 1999

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 10450692

Additional Document Info

start page

  • 1381

end page

  • 91

volume

  • 40

number

  • 8