Major involvement of CD40 in the regulation of chemokine secretion from human peritoneal mesothelial cells Academic Article uri icon

Overview

MeSH Major

  • CD40 Antigens
  • Chemokine CCL2
  • Chemokine CCL5
  • Interleukin-8
  • Peritoneum

abstract

  • In light of our data, it is reasonable to suggest that in the mononuclear phase of peritonitis, IFN-gamma and CD154, expressed by activated mononuclear cells, diminish IL-8 secretion from HPMC and thus inhibit neutrophil recruitment. At the same time, the two act in synergy to induce the secretion of RANTES and MCP-1 from HPMC. Hence, by regulating chemokine secretion, CD40 may be involved in peritonitis and in the development of late phase mononuclear predominance.

publication date

  • January 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1046/j.1523-1755.2003.00338.x

PubMed ID

  • 14633128

Additional Document Info

start page

  • 2064

end page

  • 71

volume

  • 64

number

  • 6