Induction of Fas ligand-mediated apoptosis by interferon-α Academic Article uri icon

Overview

MeSH Major

  • Diabetes Mellitus, Type 2
  • Dietary Carbohydrates
  • Dietary Fats

abstract

  • Interferon-alpha (IFN-alpha) was among the first cytokines studied and the earliest to be used in clinical medicine for the treatment of viral infections and malignancies. Although the capacity of IFN-alpha to augment NK cell cytotoxicity against virus-infected target cells or tumor cells is well established, the mechanism has not been fully elucidated. Here we report that IFN-alpha stimulation of PBMC from healthy donors induces Fas (CD95) ligand (FasL) transcription and leads to increased cell surface FasL expression exclusively on the NK cell fraction. Furthermore, IFN-alpha augments the FasL-mediated cytotoxicity of normal PBMC against Fas-sensitive lymphoid tumor cells. In the context of innate immunity, induction of FasL by IFN-alpha can be viewed as an efficient mechanism to potentiate NK cell cytotoxicity in the presence of harmful targets, such as virally infected or transformed cells.

publication date

  • June 2000

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1006/clim.2000.4866

Additional Document Info

start page

  • 218

end page

  • 26

volume

  • 95

number

  • 3