Results of recent large cholesterol-lowering trials and implications for clinical management Article Editorial Article uri icon


MeSH Major

  • Coronary Disease
  • Myocardial Infarction


  • Three recent large clinical trials-the West of Scotland Coronary Prevention Study, the Scandinavian Simvastatin Survival Study, and the Cholesterol and Recurrent Events Trial-have all confirmed that cholesterol lowering with HMG-CoA reductase inhibitors is safe and effective therapy to prevent an initial or recurrent coronary event in patients at high risk for coronary heart disease. However, a number of questions related to the treatment of lipid disorders and risk reduction for coronary heart disease remain, including the cholesterol concentration at which treatment would best be initiated, the optimal cholesterol reduction or goal to be attained, and the mechanisms by which HMG-CoA reductase inhibitors reduce the risk for clinical events.

publication date

  • June 15, 1997



  • Editorial


Digital Object Identifier (DOI)

  • 10.1016/S0002-9149(97)00218-X

PubMed ID

  • 9202359

Additional Document Info

start page

  • 1663

end page

  • 6


  • 79


  • 12