Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Academic Article uri icon

Overview

MeSH

  • Animals
  • Cell Differentiation
  • Cell Line
  • Cell Transformation, Neoplastic
  • Coculture Techniques
  • Disease Models, Animal
  • Hedgehog Proteins
  • Humans
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation
  • Oncogene Proteins
  • Transcription Factors
  • Tumor Cells, Cultured
  • Veratrum Alkaloids
  • Zinc Finger Protein GLI1

MeSH Major

  • Carcinoma, Small Cell
  • Epithelial Cells
  • Lung
  • Lung Neoplasms
  • Signal Transduction
  • Stem Cells
  • Tomatine
  • Trans-Activators

abstract

  • Embryonic signalling pathways regulate progenitor cell fates in mammalian epithelial development and cancer. Prompted by the requirement for sonic hedgehog (Shh) signalling in lung development, we investigated a role for this pathway in regeneration and carcinogenesis of airway epithelium. Here we demonstrate extensive activation of the hedgehog (Hh) pathway within the airway epithelium during repair of acute airway injury. This mode of Hh signalling is characterized by the elaboration and reception of the Shh signal within the epithelial compartment, and immediately precedes neuroendocrine differentiation. We reveal a similar pattern of Hh signalling in airway development during normal differentiation of pulmonary neuroendocrine precursor cells, and in a subset of small-cell lung cancer (SCLC), a highly aggressive and frequently lethal human tumour with primitive neuroendocrine features. These tumours maintain their malignant phenotype in vitro and in vivo through ligand-dependent Hh pathway activation. We propose that some types of SCLC might recapitulate a critical, Hh-regulated event in airway epithelial differentiation. This requirement for Hh pathway activation identifies a common lethal malignancy that may respond to pharmacological blockade of the Hh signalling pathway.

publication date

  • March 20, 2003

has subject area

  • Animals
  • Carcinoma, Small Cell
  • Cell Differentiation
  • Cell Line
  • Cell Transformation, Neoplastic
  • Coculture Techniques
  • Disease Models, Animal
  • Epithelial Cells
  • Hedgehog Proteins
  • Humans
  • Lung
  • Lung Neoplasms
  • Mice
  • Mice, Nude
  • Neoplasm Transplantation
  • Oncogene Proteins
  • Signal Transduction
  • Stem Cells
  • Tomatine
  • Trans-Activators
  • Transcription Factors
  • Tumor Cells, Cultured
  • Veratrum Alkaloids
  • Zinc Finger Protein GLI1

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/nature01493

PubMed ID

  • 12629553

Additional Document Info

start page

  • 313

end page

  • 317

volume

  • 422

number

  • 6929