Human Alu element retrotransposition induced by genotoxic stress Academic Article uri icon

Overview

MeSH Major

  • Alu Elements
  • Mutagens

abstract

  • Alu elements are found exclusively in primate species and comprise over 10% of the human genome. To better define the mechanisms responsible for Alu replication, we introduced a human Alu element into mouse cells. We report that Alu retrotransposition can be induced in mouse cells by exposure to the topoisomerase II inhibitor etoposide and is mediated in trans by endogenous mouse long interspersed elements (LINEs).

publication date

  • November 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/ng1259

PubMed ID

  • 14578886

Additional Document Info

start page

  • 219

end page

  • 20

volume

  • 35

number

  • 3