The Cholinergic Anti-inflammatory Pathway: A Missing Link in Neuroimmunomodulation Review uri icon

Overview

MeSH Major

  • Brain
  • Cholinergic Agents
  • Immune System
  • Inflammation
  • Neuroimmunomodulation

abstract

  • This review outlines the mechanisms underlying the interaction between the nervous and immune systems of the host in response to an immune challenge. The main focus is the cholinergic anti-inflammatory pathway, which we recently described as a novel function of the efferent vagus nerve. This pathway plays a critical role in controlling the inflammatory response through interaction with peripheral a7 subunit-containing nicotinic acetylcholine receptors expressed on macrophages. We describe the modulation of systemic and local inflammation by the cholinergic anti-inflammatory pathway and its function as an interface between the brain and the immune system. The clinical implications of this novel mechanism also are discussed.

publication date

  • May 2003

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC1430829

PubMed ID

  • 14571320

Additional Document Info

start page

  • 125

end page

  • 34

volume

  • 9

number

  • 5-8