Transforming growth factor beta and progression of renal disease Academic Article Article uri icon

Overview

MeSH Major

  • Cryopreservation
  • Kidney Diseases
  • Kidney Transplantation
  • Organ Preservation
  • Perfusion

abstract

  • End-stage renal disease (ESRD) is more frequent in African Americans compared to whites. Many factors may be responsible, including genetic differences, increased prevalence of risk factors, and socioeconomic factors; however, to date, these proposed genetic or environmental factors have not provided a satisfactory explanation for the increased risk of ESRD in African Americans. Because renal fibrosis is a correlate of progressive renal failure and a dominant feature of ESRD, and because transforming growth factor beta 1 (TGF-β1) can induce fibrosis and renal insufficiency, we explored the hypothesis that TGF-β1 hyperexpression is more frequent in African Americans compared to whites. We tested our hypotheses by measuring TGF-β1 levels in African Americans and white patients with ESRD, hypertension, and in normal patients. In hypertensive and normal patients, we also evaluated TGF-β1 mRNA levels, and TGF-β1 DNA polymorphisms. We demonstrated that circulating levels of TGF-β1 are higher in African American ESRD patients, hypertensive patients, and normal control patients compared to their white counterparts. We also reported that TGF-β1 mRNA levels are higher in hypertensives compared to normotensives. Our preliminary genetic analyses suggest that TGF-β1 DNA polymorphisms may distinguish hypertensives from normotensives, and our laboratory is currently investigating racial differences in TGF-β1 DNA polymorphisms. Our observations of hyperexpression of TGF-β1 in African Americans suggest a mechanism for the increased prevalence of renal failure and hypertensive target organ damage in this population.

publication date

  • November 2003

Research

keywords

  • Academic Article

Identity

PubMed ID

  • 14531781

Additional Document Info

start page

  • S99

end page

  • S104

volume

  • 64

number

  • 87