Pharmacologic inactivation of kinase suppressor of ras-1 abrogates ras-mediated pancreatic cancer Academic Article uri icon

Overview

MeSH Major

  • Genes, ras
  • Oligonucleotides, Antisense
  • Pancreatic Neoplasms
  • Protein Kinases

abstract

  • Inhibition of the kinase suppressor of ras-1 (KSR1) gene by continuous infusion of phosphorothioate antisense oligonucleotides (ODNs) prevented growth of K-Ras-dependent human PANC-1 pancreatic and A549 non-small-cell lung carcinoma xenografts in nude mice, effected regression of established PANC-1 tumors and inhibited A549 lung metastases, all without apparent toxicity. These studies suggest KSR1 antisense ODNs as a treatment for Ras-dependent human malignancies, in particular pancreatic cancer, which lacks effective curative therapy.

publication date

  • January 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/nm927

PubMed ID

  • 12960962

Additional Document Info

start page

  • 1266

end page

  • 8

volume

  • 9

number

  • 10