Response assessment classification in patients with advanced renal cell carcinoma treated on clinical trials: Effect of measurement criteria and other parameters
Carcinoma, Renal Cell
The use of unidimensional measurements in RCC therapy assessment results in significantly different time to progression classification compared with the use of bidimensional measurements. Response assessment classification in patients with RCC is affected by the exclusion or inclusion of measurements of the primary renal tumor. The normalized lesion index warrants further study in assessing response in patients with metastatic RCC and other solid tumor malignancies that often show substantial differences in sizes of measurable lesions.