Patterns of initial disease recurrence after resection of gallbladder carcinoma and hilar cholangiocarcinoma: Implications for adjuvant therapeutic strategies Academic Article uri icon


MeSH Major

  • Bile Duct Neoplasms
  • Bile Ducts, Intrahepatic
  • Cholangiocarcinoma
  • Gallbladder Neoplasms
  • Neoplasm Recurrence, Local


  • After resection, recurrent GBCA is much more likely than recurrent HCCA to involve a distant site. GBCA is also associated with a much shorter time to recurrence and a shorter survival period after recurrence. The results demonstrated significant differences in the clinical behavior of these tumors and suggested that an adjuvant therapeutic strategy targeting locoregional disease, such as radiotherapy, is unlikely to have a significant impact in the overall management of GBCA. Conversely, there is at least some rationale for such an approach in patients with HCCA based on the pattern of initial recurrence.

publication date

  • October 15, 2003



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1002/cncr.11699

PubMed ID

  • 14534886

Additional Document Info

start page

  • 1689

end page

  • 700


  • 98


  • 8