B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma Academic Article uri icon

Overview

MeSH Major

  • Antigens, CD80
  • Blood Proteins
  • Carcinoma, Squamous Cell
  • Head and Neck Neoplasms
  • Immunotherapy, Adoptive
  • Peptides

abstract

  • In this report, we demonstrate that B7-H1, a B7 family molecule implicated in tumor immune evasion, is constitutively expressed on 66% of freshly isolated squamous cell carcinomas of the head and neck (SCCHN). To define the potential impact of tumor-associated B7-H1 on immunotherapy, the B7-H1-negative mouse SCC line, SCCVII, was transfected to express B7-H1. Although all of the animals succumbed to B7-H1/SCCVII tumors even after adoptive T-cell immunotherapy, the infusion of B7-H1 blocking monoclonal antibody with activated T cells cured 60% of animals. These data support B7-H1 blockade as a new approach to enhance the efficacy of T-cell immunotherapy.

publication date

  • October 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 14559843

Additional Document Info

start page

  • 6501

end page

  • 5

volume

  • 63

number

  • 19