Disease-associated expression profiles in peripheral blood mononuclear cells from patients with advanced renal cell carcinoma Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Renal Cell
  • Kidney Neoplasms
  • Leukocytes, Mononuclear

abstract

  • Expression profiling has demonstrated that transcriptomes of primary malignancies differ from those in normal tissue. It is unknown, however, whether there exist "surrogate" transcriptional markers in peripheral blood mononuclear cells (PBMCs) of patients with solid tumors. We identified transcripts expressed differentially between PBMCs from renal cell carcinoma patients and normal subjects, some of which appear to reflect specific immune responses of circulating cells. We also identified small sets of predictor genes distinguishing PBMCs from renal cell carcinoma patients and normal volunteers with high accuracy. The present findings have important implications for diagnosis and future clinical pharmacogenomic studies of antitumor therapies.

publication date

  • September 15, 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 14522937

Additional Document Info

start page

  • 6069

end page

  • 75

volume

  • 63

number

  • 18