HIV Tat protein causes endothelial dysfunction in porcine coronary arteries
Blood Vessel Prosthesis
Blood Vessel Prosthesis Implantation
Tat protein significantly decreased endothelium-dependent vasorelaxation and eNOS mRNA and protein expression in endothelial cells of porcine coronary arteries. This study suggests that Tat protein-mediated endothelial dysfunction may be important in coronary heart disease in HIV-infected patients.