Stem cells of the skin epithelium Review uri icon

Overview

MeSH Major

  • Skin
  • Stem Cells

abstract

  • Tissue stem cells form the cellular base for organ homeostasis and repair. Stem cells have the unusual ability to renew themselves over the lifetime of the organ while producing daughter cells that differentiate into one or multiple lineages. Difficult to identify and characterize in any tissue, these cells are nonetheless hotly pursued because they hold the potential promise of therapeutic reprogramming to grow human tissue in vitro, for the treatment of human disease. The mammalian skin epithelium exhibits remarkable turnover, punctuated by periods of even more rapid production after injury due to burn or wounding. The stem cells responsible for supplying this tissue with cellular substrate are not yet easily distinguishable from neighboring cells. However, in recent years a significant body of work has begun to characterize the skin epithelial stem cells, both in tissue culture and in mouse and human skin. Some epithelial cells cultured from skin exhibit prodigious proliferative potential; in fact, for >20 years now, cultured human skin has been used as a source of new skin to engraft onto damaged areas of burn patients, representing one of the first therapeutic uses of stem cells. Cell fate choices, including both self-renewal and differentiation, are crucial biological features of stem cells that are still poorly understood. Skin epithelial stem cells represent a ripe target for research into the fundamental mechanisms underlying these important processes.

publication date

  • September 30, 2003

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC304094

Digital Object Identifier (DOI)

  • 10.1073/pnas.1734203100

PubMed ID

  • 12913119

Additional Document Info

start page

  • 11830

end page

  • 5

volume

  • 100

number

  • SUPPL. 1