Active, specific immunotherapy for lung cancer: hurdles and strategies using genetic modification. Review uri icon

Overview

MeSH

  • Animals
  • Antigens, Neoplasm
  • Gene Transfer Techniques
  • Humans
  • Vaccination

MeSH Major

  • Genetic Techniques
  • Immunotherapy, Active
  • Lung Neoplasms

abstract

  • Active immunotherapy for lung cancer has been a challenge because of the poor antigenic characterization of these tumors and their ability to escape the immune response. However, knowledge of the mechanisms of anti-tumor immunity has expanded significantly over the past decade, leading to the development of more novel, specific strategies for augmenting the immune response. Genetic manipulation of tumor cells, immune cells, or both, may help overcome some of the previously encountered difficulties of immunotherapy. Laboratory and clinical investigations are currently ongoing to evaluate the feasibility and potential benefit of these novel approaches.

publication date

  • October 2003

has subject area

  • Animals
  • Antigens, Neoplasm
  • Gene Transfer Techniques
  • Genetic Techniques
  • Humans
  • Immunotherapy, Active
  • Lung Neoplasms
  • Vaccination

Research

keywords

  • Journal Article
  • Review

Identity

Language

  • eng

PubMed ID

  • 14530047

Additional Document Info

start page

  • 1319

end page

  • 1326

volume

  • 76

number

  • 4