Stimulating PD-1-negative signals concurrent with blocking CD154 co-stimulation induces long-term islet allograft survival Academic Article uri icon

Overview

MeSH Major

  • Antigens, Surface
  • CD40 Ligand
  • Graft Survival
  • Islets of Langerhans Transplantation
  • Lymphocyte Activation
  • Proteins

abstract

  • These results suggest that engaging the negative receptor PD-1 exhibits critical immunoregulatory effects in the allograft response, and blocking positive co-stimulatory molecules with active delivery of inhibitory signals may represent a novel therapeutic strategy in transplantation.

publication date

  • September 27, 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/01.TP.0000085010.39567.FB

PubMed ID

  • 14508368

Additional Document Info

start page

  • 994

end page

  • 9

volume

  • 76

number

  • 6