Correlation of cyclooxygenase-2 expression with molecular markers, pathological features and clinical outcome of transitional cell carcinoma of the bladder Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Transitional Cell
  • Isoenzymes
  • Prostaglandin-Endoperoxide Synthases
  • Urinary Bladder Neoplasms

abstract

  • COX-2 is commonly expressed in patients with bladder TCC. Using the cutoff of 10% abnormal COX-2 expression is associated with the degree of invasiveness, alterations in TGF-beta1 and pRB/p16 pathways, and loss of cell adhesion. While COX-2 expression has limited prognostic value in patients with bladder TCC, it may serve as a target for therapy with selective COX-2 inhibitors.

publication date

  • September 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/01.ju.0000080401.85145.ee

PubMed ID

  • 12913755

Additional Document Info

start page

  • 985

end page

  • 9

volume

  • 170

number

  • 3