Severe and selective deficiency of interferon-γ-producing invariant natural killer T cells in patients with myelodysplastic syndromes Academic Article Article uri icon

Overview

MeSH Major

  • Leukemia, Myeloid, Acute
  • Myelodysplastic Syndromes
  • Neoplasms, Second Primary

abstract

  • Here we show that patients with myelodysplastic syndromes (MDS) have a severe deficiency of glycolipid reactive Valpha24+/Vbeta11+ natural killer T (NKT) cells, but not NK cells or CD4+ or CD8+ T cells. Neither the blood nor marrow of MDS patients had detectable interferon-gamma-producing NKT cells in response to the NKT ligand, alpha-galactosyl ceramide, although influenza-virus-specific effector T-cell function was preserved. This severe and selective deficiency of an important immune regulatory cell may contribute to the pathogenesis of MDS.

publication date

  • August 2003

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1046/j.1365-2141.2003.04465.x

PubMed ID

  • 12899717

Additional Document Info

start page

  • 617

end page

  • 22

volume

  • 122

number

  • 4