Design, synthesis, and biological properties of highly potent epothilone B analogues Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Epothilones

abstract

  • A number of rationally designed epoxide and cyclopropane epothilone B (1) analogues with substituted side chains were prepared and their biological activities were evaluated against a series of human cancer cell lines. The cyclopropane analogue 2 with a methylsulfanylthiazole ring stands out as the most potent compound and is sixfold more active than 1. The methylsulfanyl group enhances the potency of these compounds.

publication date

  • August 4, 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/anie.200351819

PubMed ID

  • 12900969

Additional Document Info

start page

  • 3515

end page

  • 20

volume

  • 42

number

  • 30