Experimental pulmonary aspergillosis due to Aspergillus terreus: pathogenesis and treatment of an emerging fungal pathogen resistant to amphotericin B. Academic Article uri icon

Overview

MeSH

  • Animals
  • Female
  • Lung
  • Lung Diseases, Fungal
  • Microbial Sensitivity Tests
  • Rabbits
  • Species Specificity

MeSH Major

  • Amphotericin B
  • Antifungal Agents
  • Aspergillosis
  • Aspergillus
  • Communicable Diseases, Emerging
  • Drug Resistance, Fungal

abstract

  • Aspergillus terreus is an uncommon but emerging fungal pathogen, which causes lethal infections that are often refractory to amphotericin B (AmB). In comparison to Aspergillus fumigatus, A. terreus was resistant to the in vitro fungicidal effects of safely achievable concentrations of AmB. These in vitro findings correlated directly with resistance of A. terreus to AmB in experimental invasive pulmonary aspergillosis. Residual fungal pulmonary burden and galactomannan antigenemia demonstrated persistent infection, despite therapy with deoxycholate AmB or liposomal AmB. By comparison, posaconazole and itraconazole resolved GM antigenemia, reduced residual fungal burden, and improved survival. There were no differences in phagocytic host response to A. terreus versus A. fumigatus; however, the rate of conidial germination of A. terreus was slower. The strain of A. terreus with the highest minimum inhibitory and minimum lethal concentration of AmB also had the lowest membrane ergosterol content. The hyphae of A. terreus in vivo displayed distinctive aleurioconidia, which may be a practical microscopic feature for rapid preliminary diagnosis.

publication date

  • July 15, 2003

has subject area

  • Amphotericin B
  • Animals
  • Antifungal Agents
  • Aspergillosis
  • Aspergillus
  • Communicable Diseases, Emerging
  • Drug Resistance, Fungal
  • Female
  • Lung
  • Lung Diseases, Fungal
  • Microbial Sensitivity Tests
  • Rabbits
  • Species Specificity

Research

keywords

  • Journal Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1086/377210

PubMed ID

  • 12854088

Additional Document Info

start page

  • 305

end page

  • 319

volume

  • 188

number

  • 2