Reduced folate carrier and dihydrofolate reductase expression in acute lymphocytic leukemia may predict outcome: A Children's Cancer Group study Academic Article Article uri icon

Overview

MeSH Major

  • Kidney Neoplasms
  • Wilms Tumor

abstract

  • These results suggest that impaired transport may be an important mechanism of intrinsic methotrexate resistance in ALL, and DHFR expression also may be an important prognostic factor in ALL. Additional studies are necessary to clarify the mechanism for the correlation of low DHFR expression with poor outcome.

publication date

  • September 2003

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1097/00043426-200309000-00004

PubMed ID

  • 12972803

Additional Document Info

start page

  • 688

end page

  • 95

volume

  • 25

number

  • 9