Tuberous Sclerosis Complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb Academic Article uri icon

Overview

MeSH Major

  • Arthroplasty, Replacement
  • Intervertebral Disc
  • Lumbar Vertebrae
  • Spinal Diseases

abstract

  • We show that Rheb acts as a novel mediator of the nutrient signaling input to mTOR and is the molecular target of TSC1 and TSC2 within mammalian cells.

publication date

  • August 5, 2003

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0960-9822(03)00506-2

Additional Document Info

start page

  • 1259

end page

  • 68

volume

  • 13

number

  • 15