The emergence of Ph-, trisomy -8+ cells in patients with chronic myeloid leukemia treated with imatinib mesylate Academic Article Article uri icon

Overview

MeSH Major

  • Alleles
  • Busulfan
  • Janus Kinase 2
  • Myeloablative Agonists
  • Polycythemia Vera

abstract

  • While on treatment with imatinib mesylate a small group (less than 5%) of patients with CML developed Ph(-) trisomy 8(+) clone associated with pancytopenia. None of the patients developed clinical or hematological signs of progression to a more advanced phase of CML. These observations suggest that identification of trisomy 8 cells may represent clonal Ph(-) cells that were uncovered by treatment with a selective and potent inhibitor of Ph(+) cells.

publication date

  • August 2003

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/S0301-472X(03)00176-0

PubMed ID

  • 12901975

Additional Document Info

start page

  • 702

end page

  • 7

volume

  • 31

number

  • 8