Cluster analysis of p53 and Ki67 expression, apoptosis, alpha-fetoprotein, and human chorionic gonadotrophin indicates a favorable prognostic subgroup within the embryonal carcinoma germ cell tumor Academic Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Chorionic Gonadotropin
  • Germinoma
  • Ki-67 Antigen
  • Testicular Neoplasms
  • Tumor Suppressor Protein p53
  • alpha-Fetoproteins

abstract

  • These results suggest that there is a subgroup of NSGCT patients with embryonal carcinoma (with or without other histologies) with a specific tumor biology profile (high Ki67, low apoptosis, and low p53) whose survival is better than that of the overall patient group. The unexpectedly good outcome for the prominent cluster and independent-risk status suggest that subgroups of GCT reflecting different abilities to respond to treatment exist within IGCCCG prognostic categories.

publication date

  • July 15, 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.2003.03.136

PubMed ID

  • 12860944

Additional Document Info

start page

  • 2679

end page

  • 88

volume

  • 21

number

  • 14