Microvascular function regulates intestinal crypt response to radiation Academic Article uri icon

Overview

MeSH Major

  • Jejunum

abstract

  • Recent evidence suggests that microvascular endothelial apoptosis represents the primary lesion in radiation damage to the gastrointestinal (GI) tract. Rescue of endothelium by depletion of acid sphingomyelinase or i.v. treatment with basic fibroblast growth factor (FGF) prevented the lethal GI syndrome in C(57)Bl/6 mice. Here we show that basic FGF increased crypt survival after irradiation by 2-3 fold, with a dose modification factor at D(10) of 1.15 (P < 0.01). Basic FGF inhibited initial crypt damage, assessed by crypt shrinkage at 18-24 h, but did not significantly affect the regeneration of surviving crypts at 3.5 days after irradiation. These data suggest that microvascular function regulates expression of radiation-induced crypt stem cell clonogen damage in the evolution of radiation injury to the GI mucosa.

publication date

  • August 2003

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 12907601

Additional Document Info

start page

  • 4338

end page

  • 41

volume

  • 63

number

  • 15