Bone remodeling signaled by a dihydropyridine- and phenylalkylamine-sensitive calcium channel Academic Article uri icon

Overview

MeSH Major

  • Bone Development
  • Bone Resorption
  • Calcium
  • Calcium Channels
  • Osteoblasts

abstract

  • An osteoblast calcium channel demonstrated by single channel recordings is associated with calcium antagonist receptor binding sites in osteoblast-like osteosarcoma cells. By using whole cell current recordings we now show that this channel is stimulated by the dihydropyridine calcium agonist drug BAY K 8644. A physiological relevance of these channels is apparent from the stereoselective, potent inhibition of parathyroid hormone-stimulated calcium uptake into osteoblast-like cells in culture by desmethoxyverapamil, a phenylalkylamine calcium antagonist. Secretion by these cells of the bone matrix protein osteocalcin is stimulated by BAY K 8644 and blocked by desmethoxyverapamil and nitrendipine. Evidence for a role of this channel in bone remodeling in intact animals comes from enhanced bone resorption in fetal rat bones observed with BAY K 8644 and stereoselective, potent blockade of resorption by desmethoxyverapamil.

publication date

  • January 1989

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC287039

PubMed ID

  • 2468165

Additional Document Info

start page

  • 2957

end page

  • 60

volume

  • 86

number

  • 8