Local cryoglobulin deposition in primary central nervous system lymphoma Academic Article Article uri icon


MeSH Major

  • Adenocarcinoma
  • Carcinoma, Squamous Cell
  • Carcinoma, Transitional Cell
  • Neoplasms, Multiple Primary
  • Urologic Neoplasms


  • Primary central nervous system lymphomas (PCNSLs) represent malignant non-Hodgkin's B-cell lymphomas confined to the central nervous system. Recent years have brought a dramatic increase in the frequency of PCNSL in the immunocompromised and immunocompetent populations. Cryoglobulins are cold-precipitable immunoglobulins associated with a number of infectious, autoimmune, and neoplastic disorders. Although it is known that patients with hematologic malignancies (eg, B-cell lymphomas, chronic lymphocytic leukemia, plasma cell dyscrasias) may have cryoglobulinemias and cryoglobulin deposition in several organs (eg, kidney, liver skin, blood vessels, peripheral nervous system), PCNSL associated with cryoglobulin deposition has not been previously described. This report demonstrates localized cryoglobulin deposition within the tumor bed in an immunocompetent patient with PCNSL.

publication date

  • July 2003



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/S0046-8177(03)00192-8

PubMed ID

  • 12874771

Additional Document Info

start page

  • 720

end page

  • 4


  • 34


  • 7